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Why can we give kids more Albuterol than adults?
because they metabolize the drug faster than the drug can reach its potential
What percent of Albuterol MDI actually goes to the lungs? rest goes where?
30% goes to lungs
70% to stomach
1 ML =
1 cc
1 mg=
.001 grams
500 ml=
.5L
We use mg's for?
solutions
Mcgs are used for?
inhalers
Parasympathetic controls what?
SLUD
salivation, lacrimation,urination, defication
when you stimulate, you get more
Uses ACH to create SLUD
Sympathetic controls what?
Fight or Flight
not essential to life
Uses two major receptors:
Alpha and Beta 1& 2
Parasympathomimetic does what?
stimulates parasympathetic nervous system
Parasympatholytic does what?
blocks effects of parasympathetic nervous system
Increases HR and causes bronchodilation
Sympathomimetic does what?
stimulates sympathetic nervous system
Sympatholytic does what?
blocks effects of sympathetic nervous system
Cholinergic does what?
stimulates a receptor for ACH
same as parasympathomimetic
When stimulated; the sympathetic nervous system throw these Alpha and Beta 1 and 2 into action. What do these receptors do in turn?
Alpha- stimulates vasoconstriction
Beta 1- Increases HR(think 1 heart=
beta 1)
Beta 2- causes bronchodilation
(think 2 lungs=beta 2)
Adrenergic does what?
Give an example of and adrenergic drug
stimulates a receptor for Norepinephrine and Epinephrine causing bronchodilation
Albuterol
Anticholinergic does what?
blocks ACH in turn blocking parasympathetic system
Antiadrenergic does what?
blocks Norepinephrine and Epinephrine
is a sympatholytic
Anticholinergic is parasympatholytic blocking SLUD so if we are blocking a natural derease in HR caused by SLUD then an anticholinergic would?
increase HR
Adrenergic is hand in hand with?
Sympathomimetic
Adrenergics are also referred to as?
B-agonists
meaning they stimulate B2(bronchoconstriction)
What are indications for adrenergic bronchodilators?
Relaxation of airway bronchial smooth muscle in the presence of reversible airflow obstruction
What are some short acting adrenergic bronchodilators?
Rescue inhalers?
Albuterol, levalbuterol, and pirbuterol
Long acting adrenergic brochodilators?
Salmeterol and Formoterol
Another unspecific adrenergic bronchodilator?
Racemic Epinephrine
Albuterol
(Proventil, Ventolin, ProAir)
Adult Dosage for Hand held neb
0.5ml (2.5mg) via SVN
Albuterol Dose
MDI
2 puffs of 90mcg
Albuterol Dose
DPI
1 inhalation of 200 mcg/capsule DPI
Onset of bronchodilation for Albuterol?
15 min.
Time to peak bronchodilating effect for Albuterol?
30-60 min.
Duration of action Albuterol
5-8 hours
Levalbuterol is also known as:
Xopenex
Adult dosages of Levalbuterol
0.63mg & 1.25mg
Levalbuterol MDI dose
2 puffs of 90 mcg/puff Q4-6
What 2 drugs are in Advair?
salmeterol and flovent
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