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NONSPECIFIC BODY DEFENSES
A. SURFACE MEMBRANE BARRIERS B. NONSPECIFIC CELLULAR AND CHEMICAL DEFENSES
A. SURFACE MEMBRANE BARRIERS
*1ST LINE OF DEFENSE – SKIN, MUCOUS MEMBRANES
SKIN: physical barrier C BUM
– low pH 5. Provide environment encourage a growth of normal flora.
MUCOUS MEMBRANES
A. EYES
B. NOSE AND RESPIRATORY TRACHTS
C. GI.
D. GU
EYES
blink, tears contains, lysosome – enzyme
NOSE AND RESPIRATORY TRACHTS
mucous membrane and hair help traps dust and dirt
GI.
stomach acid will kill most bacteria that get into. Bacteria on intestine.
GU
-male have long urethra;  female short urethra vagina very acidic prevent.
NONSPECIFIC CELLULAR AND CHEMICAL DEFENSES
A. MACROPHAGES
B. NEUTROPHILS
A. MACROPHAGES
stay a live after then kill bacteria
B. NEUTROPHILS
acute infiection/ destroy them cell in process in attact.
FREE MACROPHAGES
WANDER THROUGHOUT BODY
FIXED MACROPHAGES
EX. KUPFFLER CELLS IN LIVER –macro
ENGULF PATHOGEN
- > FORM PHAGOSOME (VACUOLE) - > FUSE WITH LYSOSOME
IF PATHOGEN RESISTANT TO ACID HYDROLASES OF LYSOSOME
- > RESPIRATORY BURST
OPSONIZATION
-process of handing to the bacteria; make phago cytosin. Canoy coat
NATURAL KILLER CELLS
- not phagocyte. Kills and targets diff. then use polk furines. ACTION – increase inflammation response.
INFLAMMATION
STEPS OF TISSUE RESPONSE TO INJURY
-prevent the spread of harmful substgances, swelling, pain, redness, heat
VASODILATION AND INCREASED VASCULAR PERMEABILITY
- Increase redness and increase heat and cause pain.
INFLAMMATORY CHEMICALS
A. HISTAMINE B. KININS C.PROSTAGLANDINS D. COMPLEMENT E.LYMPHOKINES
VASODILATION
HYPEREMIA
INCREASED LOCAL VASCULAR PERMEABILITY
- > EXUDATE - > EDEMA
BENEFITS EXUDATE:
- dilute harmful chemical- positive increase oxygen in area 1.make more nutrient 2. increase amt. of protein 3. isolate damage area.
PHAGOCYT MOBILIZATION
1. MACROPHAGES & NEUTROPHILS KEEP COMING 2. INJURED CELLS RELEASE LEUKOCYTOSIS-INDUCING FACTORS 3. MONOCYTES COME -> BECOME MACROPHAGES
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