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Imipramine
Fam: tricyclicMOA: block reuptake of (NE) & SEROTONIN
Desipramine
Fam: tricyclicMOA: block reuptake of NE & (serotonin)
Fluoxetine
Fam: SSRIMOA: long duration of action
Cocaine
psychomotor stimulant
Dexedrine
d-amphetamine
Methylphenidate
similar to amphetamines tx: narcolepsy & ADHD
Caffeine
methylxanthinetx: OTC products
theophylline
methylxanthinesimilar profile as caffeine except...- used as bronchodilator (smooth muscle relaxant)\"
theobromine
methylxanthine similar to caffeine except...- found in chocolate (25 mg/oz)\"
anti-depressant mechanism
down regulation of post-synaptic beta adrenergic receptors in CNS (takes 2-4 wk)leads to decreased adenylate cyclase activityhigher bood levels at same dose in non-caucasians (start @lower dose)\"
SSRI uses
depression
side effects of antidepressants
1. anticholinergic effects: dry mouth
tranylcypromine
Fam: MAOI MOA: increase NE and/or serotonin at synapse by inhibiting their metabolismtx: depression (not as effective as tricyclics for severe depression)
lithium
fam: mood stabilizerMOA: poorly understood
divalproex
fam: mood stabilizer
carbamazepine
fam: mood stabilizernot FDA approved BUT now commonly used for bipolaralso anticonvulsant\"
reserpine
anti-psychoticrauwolfia alkaloid
Phenothiazines
3 subgroups:1) Aliphatic subgroup = high dose2) piperazine subgroup = low dose3) piperidine subgroup = high dose\"
Chlorpromazine
fam: anti-psychotic
trifluoperazine
fam: anti-psychotic
thioridazine
fam: anti-psychotic
Haloperidol
fam: anti-psychotic
clozapine
fam: antypical anti-psychoticMOA: weak D2 antagonist but more potent 5-HT2 antagonist (joint serotonin activity)low incidence of extrapyramidal effects and tardive dyskinesiaassociated with high incidence of agranulocytosisregular blood testing requires\"
anti-psychotics
produce anti-everything-R blockade
benztropine
anti-muscarinicused to tx extrapyramidal effects of anti-psychotic drugs\"
incidence of extrapyramidal side effects
due to balance of anti DA & anti ACh effectsHaloperidol & Piperazines (trifluoperazine) are both low dose and have high incidencealiphatics (chlorpromazine) & piperidines (thioridazine) have lower incidence\"
choice of antipsychotic
1. acute episode: 6 wk to 1 yr w/typical antipsych2. maintenance tx for recurrent episodes3. not good response to typicals? try atypical such as clozapine\"
d-amphedamine and methylphenidate (use)
most commonly used for ADHD. Increase attention
Benzodiazepins (increase GABA receptor coupled chloride conductance leading to membrane hyperpolarization)
Chlordiazepoxide, Diazepam (peak in hour or two) and Oxazepam (preferred when hepatic impairment suspected). Anti Anxiety (CNS depressants)
Flumanezil
reduce sedateive effects of benzodiazepines after anesthesia or sedation
SSRI's
first line treatment for panic disorders. Benzodiazepines are second in line
Cluster A
odd or eccentric cluster Schizotypal Schizoid Paranoid
Cluster B
dramatic, emotional, erratic cluster Borderline Histrionic Narcissistic Antisocial
Cluster C
Anxioius, fearful behaviors and interpersonal and intrapsychic conflicts Avoidant Dependent Obsessive-compulsive
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