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Anticentromere antibodies

CREST syndrome
Antidesmoglein (epithelial) antibodies
Pemphigus vulgaris

Anti-glomerular basement membrane antibodies
Goodpasture's syndrome

Glomerulonephritis and hemoptysis
Antihistone antibodies
Drug-induced lupus

Sulfonamides, Hydralizine, Isoniazid, Phenotoin, Procainamide
Anti-IgG antibodies
Rheumatoid arthritis

Systemc inflammation, joint pannus, boutonniere deformity
Antimitochondrial antibodies
Primary biliary cirrhosis

Female, cholestasis, portal hypertension
Antineutrophil cytoplasmic antibodies (ANCA)
c-ANCA: Wegner's

p-ANCA: Microscopic polyangitis, Churg-Strauss

MPO-ANCA: Pauci-immune glomerulonephritis
Antinuclear antibodies

Anti-Smith and Anti-dsDNA

Type III hypersensitivity
Antiplatelet antibodies
Idiopathic thormbocytopenia purpura (ITP)

Bleeding, diathesis
Anti-topoisomerase antibodies
Diffuse systemic scleroderma
Anti-transglutaminase /antigliadin /anti-endomysial antibodies
Celiac disease

Diarrhea, distension, weight loss
Azurophilic granular needles in leukemic blasts
Auer rods

AML, especially promyelocytic type
Bamboo spine on x-ray
Ankylosing spondylitis

Chronic inflammatory arthritis
Basophilic nuclear remnants in RBCs
Howell-Jolly bodies

Due to splenectomy or non-functioal spleen
Sickle-cell, trauma
Basophilic stippling of RBCs
Lead poisoning
Sideroblastic anemia
Bloody tap on LP

Subarachnoid hemorrhage

Berry aneurysm, AVM
Boot shaped heart on x-ray
Tetralogy of fallot
Branching gram-positive rods with sulfur granules
Actinomyces isralii
Bronchogenic apical lung tumor
Pancoast's tumor

Can compress sympathetic chain ganglion an cause Horner' syndrome
"Brown" tumor of bone
Hemorrhage (hemosiderin) causes brown color of osteolytic cysts.

Osteitis fibrosa cystica
Cardiomegaly with apical atrophy
Chagas' disease

Trypanosoma cruzi
Cellular crescents in Bowman's capsule
Rapidly progressive crescentric glomerulonephritis
"Chocolate cyst" of ovary

Frequently involves both ovaries
Circular grouping of dark tumor cells surrounding pale neutrofibrils
Homer Wright rosettes - cells surrounded by fibers

Adrenal neuroblastoma
Ewing's sarcoma
Colonies of mucoid Pseudomonas in lungs
Cystic fibrosis

CFTR mutation in Caucasians resulting in fat-soluble vitamin deficiency adn mucous plugs
Degeneration of doral column nerves
Tabes dorsalis

3° Syphilis
Loss of proprioception, gait ataxia, +Rhomberg
Depigmentation of neurons in substantia nigra
Parkinson's disease

Basal ganglia disorder
Rigidity, resting tremor, bradykinesia
Disarrayed granulosa cells in eosinophilic fluid
Curshmann's spirals

Bronchial asthma
Can result in whorled mucous plugs
Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia

Perinuclear cytoplasmic clearing
HPV 16, 18 predisposes to cervical cancer
Enlarged cells with intranuclear inclusion bodies
"Owl's eye" appearance of CMV
Eosinophilic cytoplasmic inclusion in liver
Mallory bodies

Alcoholic liver disease
Eosinophilic cytoplasmic inclusion in nerve cell
Lewy body

Parkinson's disease
Lewy body dementia
Eosinophilic globule in liver
Councilman body

Viral hepatitis
Yellow fever
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Rabies virus
Extracellular amyloid deposition in gray matter of brain
Senile plaques

Alzheimer's disease
Giant B cells with bilobed nuclei with prominent inclusions (Owl's eyes)
Reed-Sternberg cells

Hodgkin's lymphoma
Glomerulus-like structure surrounding vessel in germ cells
Schiller-Duval bodies

Yolk sac tumor
"Hair-on-end" (crew cut) appearance on x-ray
Bone marrow expansion

β-thalassemia, Sickle cell anemia
hCG elevated
Hydatidiform mole
Heart nodules (inflammatory)
Aschoff bodies - focal myocardial inflammationw tih multinucleated giant cells

Rheumatic fever
Heterophile antibodies (IgM)
EBV infectious nucleosis
Hexagonal, double-pointed, needle-like crystals in bronchial secretions
Bronchial asthma

Charcot-Leyden crystals - eosinophilic crystals
High levels of D-dimers
Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Ghon complex

1° TB
Mycobacterium tuberculosis
"Honeycomb lung" on x-ray
Interstitial fibrosis
Hypersegmented neutrophils
Megaloblastic anemia

B12, folate deficiency
Hypochormic, microcytic anemia
Iron deficiency anemia
Lead poisoning
Thalessemia - HbF sometimes present
Increased α-fetoprotein in amniotic fluid/maternal serum
Spina bifida
Abdominal wall defects
Increased uric acid levels
Lesch-Nyhan syndrome
Tumor lysis syndrome
Loop and thiazide diuretics
Myeloproliferative disorders
Intranuclear eosinophilic droplet-like bodies
Cowdry type A bodies

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