keywords:
Bookmark and Share



Front Back
Dantrolene
(20mg/50cc sterile H2O)
2.5 mg/kg IV q 5 min. until termination of episode
up to max. dose of 10 mg/kg
Succinylcholine
Rapid onset:  30-60 sec
Short duration:  3-10 min
Dose:  1-1.5 mg/kg IV
4-5 mg/kg IM in children
Steroid Derivatives
tend to be vagolytic
Pancuronium
Rocuronium
Vecuronium
Pipecuronium
Benzylisoquinolines
tend to release histamines
d-tubo
Atracurium
Mivacurium
Long Acting
Pancuronium
Doxacurium
Pipercuronium
d-tubocurarine
Metocurine and Gallamine
Intermediate Acting
Vecuronium
Atracurium
Cisatracurium
Rocuronium
Short Acting
Mivacurium
Pancuronium
(pavulon)
intub.= .08-.12 mg/kg           maint.= .01 mg/kg

Excretion primarily renal (up to 80%)

Can stimulate the SNS and block vagus therefore may see ^ HR
Doxacurium
intub.= .05 mg/kg (onset 4-6 min.) ¨           maint.= .005 mg/kg
Pipercuronium
Intub. = .06-0.1 mg/kg IV
nDTc
d-tubocurarine
Not used for NMB, but for pre-tx with suxx to prevent fasciculations
3mg IV 3-5 min. before suxx
Vecuronium
intub.= .08-.12 mg/kg           maint.= .01 mg/kg
infusion= 1-2 mcq/kg/min


Onset:  3-5 min
Duration of action under 1 hr (20-60)
Primarily biliary excretion; secondary renal excretion (25%)
Atracurium
(tracrium)
intub.= 0.5 mg/kg over 30-60 sec maint. = 0.1 mg/kg
infusion= 5-10 mcq/kg/min

Hoffman elimination : Laudanosine

CNS stimulant

SE:  histamine
Cisastracurium
(Nimbex)

intub.= 0.1-0.15 mg/kg
infusion= 1-2 mcq/kg/min
Hoffman elimination: Laudanosine but less than atracurium
Rocuronium
(zemuron)
very rapid ~30-90 sec
Can be used as an alternative to suxx for RSI
Dose:  intub.= .6 mg/kg **Rapid sequence= 1.2 mg/kg  (will make onset more rapid and longer duration)
Mivacurium
(mivacron)
Duration 12-20 minutes

intub.= .15-.2 mg/kg
infusion= 4-10 mcq/kg/min

Metabolism is via hydrolysis by plasma cholinesterase

if atypical plasma cholinesterase prolonged block
Histamine release, push more slowly to decr.

Spont. Recovery from block is rapid and need for reversal is controversial
x of y cards