Studydroid is shutting down on January 1st, 2019

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Name the drugs that inhibit hepatic enzymes? (6)
1. Cimetidine 2. Amiodarone 3. Macrolide Abx (erythromycin) 4. Metronidazole 5. Cyclosporine 6. Ketoconazole and other azole antifungals.
What are the benefits of Hormone replacement therapy in women?
1. Decreased osteoperosis 2. decreased incidence of fractures 3. reduced hot flushes 4. Less GU dryness, urgency, atrophy induced incontinence, or freq.
What are the risks to hormone replacement therapy in a post menopausal woman?
1. Increased risk of endometrial cancer (risk eliminated by coadmin with progesterone) 2. Venous Thromboembolism 3. Gal-Bladder disease 4. Breast CA risk increases after 10 or more years of use.
What are the side effects of hormone replacement therapy?
Endometrial bleeding, breast tenderness, nausea, bloating, and headaches. (think Sx of severe PMS)
What are absolute contraindications to Hormone replacement therapy?
1. Unexplained Vaginal Bleeding 2. Liver disease 3. Hx of thrombophlebitis or thromboembolism 4. Hx of endometrial or breast CA.
In a patient that you are about to start HRT on who has a history of unexplained bleeding, what should your initial evaluation include?
D&C to R/O hyperplasia and cancer.
Why is progesterone often given in HRT? When should you not prescribe progesterone to a pt receiving HRT?
Used to eliminate risk of endometrial CA... do not give to women who have no Uterus.
What are the absolute contraindications to OCP?
1. Pregnancy 2. Smoking after 35 3. Liver Dz 4. Hyperlipidemia 5. Uncontrolled HTN 6. DM with vascular changes 7. prolonged immobilization of extremity 8. Hx of thromboembolism 9. CAD, stroke, sickle cell dz. 10. Breast or Endometrial neoplams (estrogen dependent) 11. Liver adenoma 12. Hx of Cholestatic jaundice of pregnancy.
What is the most common cause of secondary HTN in women? What should you do if you notice an increased BP in your patient?
OCP use D/C OCP and recheck BP at a later date.
What are some common side effects of OCPs?
1. Glucose intolerance 2. depression 3. Edema 4. weight gain 5. Cholelithiasis 6. Benign Liver adenomas 7. melasma 8. Nause, Vomiting, Headache 9. HTN 10. Drug interactions (rifampin and antiepileptics induce metabolism of OCPs and reduce effectiveness)
Effects of Aspirin Toxicity?
Tinnitus, Vertigo, Respiratory Alkalosis, Metabolic Acidosis, hyperthermia, coma, and death.
Hypersensitivity reactions are most common in which group of patients taking aspirin?
Asthmatics and Pt. with nasal Polyps.
S/E: Trazodone
S/E: Aspirin
GI Bleed, Hypersensitivity
S/E: Bleomycin
Pulmonary Fibrosis
S/E: Cyclophosphamide
Hemorrhagic Cystitis
S/E: Bupropion
Seizures (contra-ind. in anorexics)
S/E: Isoniazid
Vit. B6 Def. Lupus like syndrome Liver Toxicity
S/E: Cyclosporine
Renal Toxicity
S/E: Penicillins
Anaphalaxis Rash with EBV
S/E: ACE inhibitors
Angioedema Cough
S/E: Demeclocycline
S/E: Lithium
DI, Thyroid Dysfx
S/E: Methoxyflurane
S/E: Sulfa Drugs
Allergies, Kernicterus in neonates
S/E: Halothane
Liver Necrosis, Malignant Hyperthermia
S/E: Local Anesthetic
S/E: Phenytoin
Folate Def. Teratogenic Hirsutism
S/E: Vincristine
Peripheral Neuropathy
S/E: Amiodarone
Thyroid Dysfx
S/E: Valproic Acid
Neural Tube Defects in kids
S/E: Thioridazine
Retinal Deposits, Cardiac Toxicity
S/E: Heparin
Thrombocytopenia Thrombosis
S/E: Clofibrate
Increased risk of GI neoplasms
S/E: Tetracycline
Photosensitivity, Teeth staining in kids
S/E: Quinolones
Teratogen --> Cartilage Damage
S/E: Quinine
Cinchoism (tennitus, Vertigo)
S/E: Morphine
Sphincter of Oddi spasm
S/E: Clindamycin
Pseudomembranous Colitis
S/E: Chloramphenicol
Aplastic Anemia, Gray Baby syndrome
S/E: Doxorubicin
S/E: Busulfan
Pulmonary Fibrosis
S/E: MAO inhibitors
Tyramine Crisis (HypOtension after eating cheese or wine)
S/E: Hydralazine
Lupus Like Syndrome
S/E: Procainamide
Lupus Like Syndrome
S/E: Minoxidil
S/E: Aminoglycoside
Hearing loss, Renal Tox.
S/E: Chlopropamide
S/E: Oxytocin
S/E: Opiates
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