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Where do the sensory neuron axons go (physicly)
neural touch pathways travel up the Dorsal Column. Once it gets to the brain stem the lines cross over to the other brain side.
dermatome
is a strip of skin innervated by a single spinal root
Seconddary somatosensory cortex
is a backup system for the primary one, it has all the same functions
Congenital insensitivity to pain
inherited syndrom due to mutation of sodium channel in apin C fibers in dorsal root ganglia
What happens when ur hit by a hammer
WHen you are hit by a hammer, cells are dammaged and they release chemicals, these chemicals then activiate the unmylinated c-fibers
Free nerve endings
in skin have specialized receptor proteins and respond to temperature change, chemicals, and tissue injury
Capsacin
the \\\"hot\\\" in chili peppers activates C fibers via TRPV receptors and is neurotoxic. The sensors are dammaged by capsation and hence produce tolerence
Substance P
neurotransmitter involved in pain and heat,
Periaqueductal gray
in the midbrain involved in pain perception; opiod receptors
mesoderm
middle layer of early embryo, turns into bones, connective tissue, muscles
Ectoderm
nervous system, and skin(maybe on the skin)
Endoderm
becomes internal lining of the stomakc/ intestense
Neurogenesis
mitosis produces neurons
Cell migration
cells move to establish distinct populations
Differentiation
cells become distinctive neurons or glial cells
Synaptogenesis
establishment of synaptic connections (Autism)
Neuronal cell death
selective death of some nerve cells (Fragile X syndrome)
Synapse rearrangement
loss or development of synapses, fine-tuning
astrocytoma
occuers often during differentiation, is a type of cancer made out of astrocytes that keep tuernign themselves into stem cells
Sonic hedgehog
cells in the notochord release a protein (Sonic hedgehog) that directs some cells in the spinal cord to become motoneurons
Induction
is the influence of one set of cells on the fate of nearby cells.
Neurotrophin
Neurotrophins are a family of proteins that induce the survival,[1] development and function[2] of neurons. They belong to a class of growth factors, secreted proteins, which are capable of signaling particular cells to survive, differentiate, or grow.[3] Growth factors such as neurotrophins that promote the survival of neurons are known as neurotrophic factors. Neurotrophic factors are secreted by target tissue and act by preventing the associated neuron from initiating programmed cell death - thus allowing the neurons to survive. Neurotrophins also induce differentiation of progenitor cells, to form neurons
Amblyopia
impairment of vision in one eye causes inability to see clearly
ApoE
ß-amyloid is broken down by apolipoprotein (ApoE). Failure of ApoE allows amyloid to accumulate, which kills the cell.
Protein tau
Protein tau stabilizes microtubules. In AD, tau changes so microtubules collapse, and tau proteins clump to form neurofibrillary tangles.
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