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Adaptive immunity
\\\"The part of the immune system that is specific and has memory -T cells
Antibodies
Molecules that are secreted by plasma cells. They bind antigen in a specific manner
Antigen
Classic definition - molecules that have specific sequences to whic adaptive immune response can be generated
Antigenicity
a property of molecules to which an adaptive immune response can be generated
antigenic derminant
a particular component of an antigen that is recognized by unique lymphocyte receptors; (that component of an antigen that is recognized by B cells or T cells ) (T cells only recognize antigens displayed with MHC; lecture 3)
Burse of Fabricius
Site of B cell maturation from progenitor cells in chickens
complement
a host defense system consisting of soluble and membrane bound proteins
chemokines
small molecules that were originally identified because of their role in attracting cells to a particular region (chemotaxis)
cytokines
molecules that are secreted primarily (but not solely) by cells of the immune system. These molecules play an important role in the activation and in down regulation of immune responses
Determinant
\\\"an antigenic determinant
epitope
\\\"an antigenic determinant
Follicle associated epithelium
The region of the lumenal epithelium that is not covered by mucus
Germinal Center
the component of a follicle where antigen induced b cel differentiation occurs
Hapten or carrier
A small molecule (<6kD) that is not immunogenic unless it binds to a protien; (carrier); carrier - a protein to which a small molecule (<6kD) has bound permitting an anti-hapten immune response
hematopoiesis
a term used to refer to the differentiation of various cell types from a pluripotent stem cell. cytokines play an important role in this process.
immunogenicity
a term used synonymously with the classical deffinition of antigenicity - refers to a molecule that can serve as the stimulus for an adaptive immune response
innate immunity
\\\"the component of immunity in which the cells are effectors and do not have memory
mitogen
polyclonal activator
peiarterial lymphatic sheath (PALS)
region that contain the white pulp
white pulp
the region of the spleen within the periarterial lymphatic sheath (PALS); predominant immune cell is the T cell and where primary T cell response can occur.
tolerance
refers to the fact that the immune system is not pathogically activated in the presence of its own
Adhesion molecules
a molecule on one sell surface that interacts with a counter molecule on another cell causing cells to adhere together
anaphylatoxins
complement protien fragment that binds to receptors on mast cells and basophils causing their degranulation
Antibody dependent cell mediated cytotoxicity (ADCC)
destuction of cells by natural killer cells following intercation with the Fc region of the IgG bound to the cell or microbe
Basophils
circulating cells that degranulate; counter part of mast cells
C-reactive protein (CRP)
an inflammatory protein that acts as opsonin. It is secreted by hepatocytes following stimulation with IL-6
C3
a complement protein that is central to both the alternate and the classical pathways of complement
C3a
a proteolytic fragment of complement - functions as anapylatoxin
C3b
a proteolytic fragment of complement - functions as opsonin
C5a
a proteolytic fragment of complement - functions as anapylatoxin
Chemokines
Molecules that serves to attract cells expressing cognate receptors on the cell surface
Chemotactic molecule
\\\"Molecules that serves to attract cells expressing cognate receptors on the cell surface
Chloride ion
an ion that plays a role in host defense in the presence of hydrogen peroxide
Chronic granulomatous diease
a genetic disorder that results in an inability to destroy antigen in the phagosome
Diapedesis (inflamation)
The process of moving from the blood vessel into the tissue
Eosinophils
cells that play an importnat role in the host immunity to helminths (worms)
Eosinophil Cationic Protein (ECP)
protien secreted by eosinophils - it is toxic to helminths
FceR
Receptor for IgE Fc region
FgyR
receptor for IgG Fc region
Hepatocytes
Liver cells
Hydrogen peroxide
Molecule produced in the phagosom during the biochemical cascade that follow activation of NADPH
Hydroxyl ion
one of the reactive oxygen intermediates (ROI) produced following the activation of NADPH oxidase; plays a role in destruction of microbes with in the phagosome
Hydroxyl radical
one of the reactive oxygen intermediates (ROI) produced following the activation of NADPH oxidase; plays a role in destruction of microbes with in the phagosome
Hypochlorite
\\\"formed following intercation of hydrogen peroxide
IgE
antibody that plays a role in host defense to helminths (and allergies)
IgG
antibody that plays an important role in ADCC by NK cells and opsonin mediated phagocytosis by phagocytes
Inducible nitric oxide synthase (iNOS)
enzyme that requires IFNy for its induction - enzyme required for the generation of nitric oxide in pagosytes
IFNy interferon Gamma
interferon Gamma is a cytokine that is secreted by helper T cells (CD4 + Th1)
Interleukin 10 (IL-10)
cytokine that is inhibitory for antigen presenting cell secrection of cytokines (e.g. IL-12)
interleukin 4 (IL-4)
Cytokine that plays and important role in the switch from IgM to IgE antibodies on the B cells
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