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Chronic Granulomatous Disease (CGD)
An inherited disorder of phagocytic cells in which the cells do not properly capture and destroy foreign invaders; this leads to recurrent life-threatening bacterial and fungal infections.
Cold hemagglutinin disease
Autoimmune disease with high concentrations of antibodies to red blood cells. The antibodies react at temperatures below body temperature.
Donath-Landsteiner antibody
An IgG antibody that binds to red blood cells in the cold and fixes complement; lysis occours when cells are warmed to 37 degrees C.
Glycophorin
A glycoprotein that projects through a red blood cell membbrane; may carry blood group antigens.
Hydatid cyst fluid
Fluid from a cyst of the liver (hydatid cyst) caused by a tapeworm; the fluid is used to inhibit anti-P1.
Paroxysmal cold hemoglobinuria (PCH)
A cryopathic hemolytic syndrome; is an autoimmune hemolytic anemia due to cold-reacting autoantibodies.
Sialoglycoproteins
Glycoproteins that carry sialic acid; the sialic acid lends a negative charge to the red blood cell membrane.
Universal antigen
An antigen found on the red cells of a large percent of the population approaching 100%.
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