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displayed only by helper T cells
CD4
displayed only by cytotoxic T cels
CD8
found on all T cells (except NK cells)
CD3
used to ID B cells
CD 19, 20, 21; IgM, IgD
found on all NK cells - binds constant region of IgG
CD16
inhibits complement C9 binding
CD 55, 59
endotoxin receptor on macs
CD14
helper T cells
CD4, TCR, CD3, CD28, CD40L
cytotoxic T cells
CD8, CD3, TCR
B cells
IgM, IgD, CD 19, 20, 21 (EBV), CD 40, MHC II, B7
macrophages
MHC II, B7, CD40, CD14; Fc and C3b receptors
NK cells
MHC I rceptors, CD 16 (binds Fc of IgG)
all cells except mature rbc\\\'s
MHC I
wbc\\\'s, rbc\\\'s, platelets
CD 55, 59 (protect against complement-mediated damage)
promotes B cell growth and differentiation; isotype switching
IL 4, IL 5
produced by Th1 cells
IL 2, IFNg
produced by Th2 cells
IL 4, IL 5, IL 10
growth and activation of eosinophils
IL 5
secreted by Th cells and activates macs
IFNg
inhibits macrophage activation
IL 10
pyogens secreted by monocytes and macrophages (mediate inflammation
IL 1, IL 6, TNFa; aka acute phase cytokines
inhibits production of Th1 cells
IL 10
inhibits production of Th2 cells
IFNg
enhances synthesis of IgE and IgG
IL 4
enhances synthesis of IgA
IL 5
released by virally infected cells
IFNa, IFNb
supports growth and differentiation of bone marrow stem cells
IL 3
supports T cell proliferation, differentiation, activation
IL 2
cytokine pneumonic (IL 1 -IL 5)
Hot T-Bone stEAk
PMN chemotactic factors
IL 8, C5a, leukotriene B4
secreted by macrophages. Causes acute inflammation. Undiced chemokine production to recruit leukocytes; activates endothelium to express adhesion molecules. Endogenous pyogen.
IL1
secreted by Th1 cells. Stimulates development of Th and Tc in thymus from T cell precursor (bone marrow)
IL2
secreted by activated T cells. Supports growth and differentiation of bone marrow cells. Function similar to GM-CSF.
IL3
secreted by Th2 cells. Promotes growth of B cells. Enhances class switching to IgE > IgG. Promotes maturation of Th2 cells.
IL4
secreted by Th2 cells. Promotes growth of B cells. Enhances class switching to IgA. Stimulates production + activation of eosinophils.
IL5
secreted by Th cells and macrophages. Stimulates production of acute phase reactants and immunoglobulins.
IL6
secreted by macrophages. Major chemotactic factor for neutrophils.
IL8
secreted by Th2 cells. Activates Th2, inhibits Th1 and macrophages.
IL10
secreted by B cells and macrophages. Activates NK and Th1 cells.
IL12
secreted by Th1 cells. Stimulates macrophages. Activates Th1, inhibits Th2.
IFN-gamma
secreted by macrophages. Mediates septic shock. Causes leukocyte recruitment, vascular leak
TNF-alpha
kills virus infected, neoplastic, and donor graft cells
CD8+ cytotoxic T cell
makes IL2, IFNg; activates macrophages and CD8+ T cell; inhibited by IL10, activated by IL12
CD4+ helper T cell: Th1 (cell mediated response)
makes IL4, IL5, IL10; helps B cells make antibody (IgE>IgG); inhibited by IFNg, activated by IL4
CD4+ helper T cell: Th2 (humoral response)
target of immunosuppresant drugs
IL2
main antibody in secondary (delayed) response to an antigen. Most abundant. Fixes complement, crosses the planceta (passive immunity to infants), opsonizes bacteria, neutralizes bacterial toxins and viruses.
IgG (half life = 21d)
prevents attachment of bacteria and viruses to mucous membranes; does not fix complement. Monomer (circulation), dimer (secreted). Found in secretions (tears, saliva, mucus) and breast milk (aka colustrum). Picks up secretory component from epithelial cells before secretion.
IgA (think mucus!)
produced in the primary (immediate) response to an antigen. Fixes complement but does NOT cross placenta. Antigen receptor on B cell surface (monomer or pentamer). Pentamer shape allows it to efficienctly trap free antigens out of tissue while humoral response evolves.
IgM (think NEW infection)
unclear fxn. Found on surface of B cells and in serum.
IgD
binds mast cells and basophils; cross links when exposed to allergen, mediated immediate (type I) hypersensitivity via release of inflammatory mediators (histamine). Mediates immunity to worms by activating eosiniphils. Lowest concentration in serum.
IgE (think allergic response!)
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