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prevent feelings of tension or fear
anxiolytics
make GABA more effective
benzodiazepine
acute narrow angle glaucoma is a contraindication with what class of meds?
benzodiazepines
acute alcohol intoxication, liver disorders are contraindicated with what class of meds?
benzodiazepines
what class of meds should be used with caution in elderly people because of unpredictable reactions?
benzodiazepines
what increases the effects of benzodiazepines?
cimetidine [tagamet], disulfiram [helps alcoholism], and oral contraceptives
what decreases the effects of benzodiazepines?
theophylline or ranitidine [zantac]
Diazepam [benzodiazepine] overdose
confusion
seizures
abnormal perception of movement
respiratory depression
excessive sedation
what anxiolytic and hypnotic med must be tapered off over 2 weeks?
chloral hydrate [Aquachloral]
abrupt stop of anxiolytic and hypnotic meds can cause...
withdrawal effects such as
insomnia
seizures
palpitations
the number or sensitivity of post synaptic receptors may increase, depleting what levels?
neurotransmitter levels

so increase of post synaptic receptors deplete neurotransmitter levels
reduces or inhibits the reuptake of 5HT and NE into nerves
TCA\'s [line]
what are contraindications of TCA\'s
liver disease
dry mouth
pregnancy & lactation
recent MI
myelography
known allergy
TCA\'s adverse reactions
dry mouth
sedation
fatigue
hallucinations
ataxia
constipation
nausea
vomiting
sleep disturbances
Phenelzine [Nardil] Naedine
MAOI\'s used for patients whi did not respond to newer safer antidepressants.
Tranylcypromine [Parnate]
Used for adult outpatients with reactive depression
MAOI\'s peak in...
peak 2 to 3 hours
MAOI\'s adverse reactions
hypoglycemia
MAOI\'s drug to drug interactions
other antidepressant - hypertensive crisis, coma
insulin or oral diabetic agents - additive hypoglycemia
no OTC meds should be taken
SSRI\'s adverse reactions
indomnia,
headache,
tremor,
agitation,
weight loss,
dry mouth
how are Alferon-N produced?
they are interferons produced by harvesting human leukocytes & injected directly into warts
how is avonex produced?
Chinese hamster ovary cells
actions of interferons
preventing virus particles from replicating inside other cells
what interleukins produced by?
dna technology using E Coli
3 things inteferons are used for
viral infections
autoimmune disorders
cancer
inhibits tumor cells and enhances the immune response
interferon
chemicals produced by T cells to communicate between leukocytes
Interleukins
avoid these while on interferons
oral contraceptives & alcohol
[neumega] oprelvekin
interferons for chemo
increase the amount of killer cells and stop tumor growth
interleukins
increase production of regular cells
inteferons
Aldesleukin
interleukin med known to stop the growth of tumors
immun stimulators diagnosis
acute pain related to CNS, GI, and flu like symptoms.
patients on immune stimulators should be taught to avoid what
avoid pregnancy use barrier method.
Cyclosporine [sandimmune]
Suppression of rejection in transplant patients, RA, and psoriasis
immune suppressors are used with?
corticosteroids, especially wit trasplant pts because they block the effects of the normal immune system
prevents rejection of transplant patients. used for patients who have not responded to traditional rheumatoid arthritis therapy
Anakinra
antibodies that attach to specific receptors
monoclonal antibodies
nursing diagnosis for immune suppressors
acute pain related to CNS, GI, and flu iike effects
interleukin receptor antagonist interactions
etanercept may cause severe / life threatening infections
it\'s provided by stimulating production of antibodies to a specific anntigen
active immunity
preformed antibodies are injected into the system and react eoth specific antigen.
passive immunity
limited immunity
passive immunity
lifelong immunity
active immunity
recommended for all children who have not been exposed to varicella
chickenpox vaccine
when is MMR vaccine given?
12 to 15 months and between 4 to 6 years old
give what vaccine for small pox?
dryvax
pneumococcal vaccine is given
once in a lifetime or again when over 65 years old.
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