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Define chemical name
  • The name indicating the drugs chemical structure
  • ex: 3-methoxy-N-o-tolysulfonylbenzamide
Define code name
  • Name assigned by a manuf to an experimental chemical that shows potential as a drug
  • Ex: aerosol SCH 1000
Define generic name
  • Name assigned by the USAN Council when chemical appears to have therapeutic use and manufacturer wishes to market
  • Name often loosely based on chemical structure
  • Ex: Albuterol
Define official name
  • Generic name becomes official name when drug is fully approved and admitted to USP-NF
Define trade name
  • Brand name or proprietary name given by manufacturer
  • Ex: albuterol is Ventolin
Three basic phases of drug action
  • Pharmaceutical
  • Pharmacokinetic
  • Pharmacodynamic
Define pharmaceutical phase
  • The drug becomes available for absorption 
  • The dosage form and route of administration affect the availability
Define Pharmacokinetic phase
  • Describes the amount of drug in the body over time and is influenced by : absorption, distribution, metabolism, elimination
TI = LD50
      _____
       ED50

Explain the meaning of this formula
  • The closer the ED50 is to the LD50 the more toxic the drug and smaller the TI
Define Central Nervous system
  • Sensory (afferent) neurons
  • Somatic (motor) neurons
  • Autonomic nervous system- Sympathetic, Parasympathetic
Advantages of inhalation route
  • Smaller doses required
  • More rapid onset of action
  • Minimal side effects
  • Convenient and easily tolerated
  • 2nd only to IV in achieving theraputic levels
Signals that are transmitted to the brain and spinal cord
  • Afferent
Signals that are transmitted from the brain and spinal cord
  • Efferent
Describe Pharmacodynamic phase
  • The interaction of the drug with it's receptor site ex: affinity, efficacy, agonist, antagonist
What are cholinergic receptors at parasympathetic end sites called ?
  • Muscarinic
Clinical use of parasympatholytics
  • In COPD relieving bronchospasm
  • In asthma used in combination with sympathomimetics
Where is Ach (Acetylcholine) a neurotransmitter ?
  • ANS- Parasympathetic branch
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