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Aminoglycoside properties
very water soluble, very polar, very basic (3 to 5 amino groups)
Aminoglycoside MoA
bind to outer lipopolysacchaaride of gram (-) organisms
then bind to 16s rRNA of 30s subunit
induciton of misreads
nonfucntional proteins disrupt bacterial cell wall allow for influx of antibiotics
Kanamycin (can/not) by autoclaved
Streptomycin (can/not) be autoclaved
Aminoglycosides oral absoption
not absorbed
Aminoglycoside distribution
all tissue except CNS and eye
Aminoglycoside metabolism
Aminoglycoside adverse effects
ototoxicity, nephrotoxicity, 
neuromuscular blockade (uncommon)
Aminoglycoside mechanism of resistance
efflux pumps  (particularly in gram (-) organisms)
O-phosphorylation of agents by bacterial phosphotransferases (Staphyococcus)
16s rRNA methylase (some ESBL organisms)
Aminoglycoside drug interactions
beta-lactam, antihistamines, anti-nausea, NSAIDs
Amikacin use
for most Gram (-)
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