by jdoby


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Actinomyces and Propionibacterim propionica characteristic
non acid fast
nonmotile
cultured on rich medium
aerobically and anaerobically

spider colony
Epidemiology of Actinomyces and propionibacterium
cause Actinomycosis

cervicofacial ,thoracicor abdominal actinomycosis
Bacillus colony
White colony with irregular margins
Sporulation Not inhibited by aerobic incubation helps
distinguish from Clostridium, an anaerobe gram + bailli spore former
One of the most highly pathogenic organisms known to mankind
Bacillus anthracis
Related to Food poisoning 
more common than anthrax
Bacillus cereus
Bacillus species 
Habitat
*Extreme temperatures
*Ubiquitous
*Extreme Acidity and alkalinity
Bacillus anthracis infects
*herbivorous animals --> human via wool and hair
Bacillus anthracis was completed using
seawater and formaldehyde
Bacillus anthracis infection route
*Cutaneous anthrax
*Pulmonary anthrax
*Gastrointestinal anthrax
3 proteins of Exotoxin
in Bacillus anthracis
*Edema factor
*Protective antigen
*Lethal factor
Edema factor is
the extracellular form of adenylate cyclase

*phagocytes
*cAMP
*impairs phagocytic ability
Protective antigen promotes
entry of EF into phagocytes
Lethal factor causes
pulmonary edema and death in rats
activity in humans poorly understood
may destroy macrophages
Bacillus anthracis specimen processing
Very contagious
Better send suspected anthrax to the state lab
Bacillus anthracis isolation and identification
Large Gram positive 
Blood agar with nonhemolytic
Irregular gray, flat
MEDUSA HEAD
Bacillus cereus toxin mediated disease
not an infection

TOXICITY
Bacillus cereus is normal
intestinal flora, isolation of organism from fecal specimens is irrelevant
Bacillus cereus produces two toxins
Emetic toxin == Vomiting

Enterotoxin == diarrhea
Emetic toxin is
heat stable toxin

behaves like staph food poisoning
enterotoxin resemble
Clostridium perfringens infection
Bacillus cereus on blood agar
beta hemoysis
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