by mtoom


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Basal cell carcinoma
  • Common/uncommon
  • Risk of metastasis
  • Linked to long-term exposure to what?
  • Common
  • Very low risk of metastasis
  • Linked to long-term exposure to sun
Basal cell carcinoma
  • 5 pathologic features and their clinical correlates

Pathology
  • Dermal nests of basaloid cells surrounded by a rim of mucin (translucent, pearly appearance)
  • Epidermis usually intact (smooth surface)
  • Sometimes ulceration (if lesion is more advanced)
  • Peripheral palisading
  • Sometimes melanin in tumour cells (sometimes pigmentation)

Clinical Correlates
  • Translucent, pearly appearance
  • Smooth surface
  • Ulceration if advanced
  • Sometimes pigmented
  • Telangiectases 
Squamous cell carcinoma
  • Linked to long-term exposure to what?
  • How differentiated from actinic keratosis?
  • Linked to long-term exposure to sun
  • Same as actinic keratosis except has dermal invasion
Squamous cell carcinoma
  • 3 pathologic features and their clinical correlates 

Pathological features
  • Penetration of tumour epithelium into dermis (nodularity or induration)
  • Hyperkeratosis, excess surface keratosis (rough scale)
  • Enlargement and pleomorphism of keratinocytes with abundant eosinophilic cytoplasm (potential for metastasis)

Clinical correlates
  • Nodularity or induration
  • Rough scale
  • Potential for metastasis 
Actinic keratosis
  • What is it?
  • Where does it occur?
  • Progresses into what? 
  • Common sun-induced premalignant lesions
  • Within the epidermis
  • Sometimes progress to invasive squamous cell carcinoma 
Actinic keratosis
  • 4 pathologic features and their clinical correlates 

Pathologic feature
  • Confinement of proliferation to epidermis (lack of nodularity or induration)
  • Sharply demarcated columns of compact hyperkeratosis and parakeratosis (sharp demarcation, roughness, and scale)
  • Subtle enlargement and pleomorphism of keratinocytes
  • Dermal inflammatory cells (red planar papule or plaque)

Clinical correlate
  • Lack of nodularity or induration
  • Sharp demarcation, roughness and scale
  • Red planar papule or plaque 
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